EPIC SANA Lisboa Hotel is located in Lisbon's City Center neighborhood, close to Amoreiras Shopping Center, Castle of Sao Jorge, and Gulbenkian Museum. Nearby points of interest also include Rossio Square and Santa Justa Elevator.

Dining options at EPIC SANA Lisboa Hotel include 2 restaurants. 2 bars/lounges are open for drinks. Room service is available 24 hours a day. Recreational amenities include an outdoor pool, an indoor pool, and a 24-hour fitness facility.

The property's full-service health spa has body treatments, massage/treatment rooms, and facials. This 5-star property offers small meeting rooms and audiovisual equipment. Complimentary wireless Internet access is available in public areas. This Lisbon property has 1760 square meters of event space consisting of a conference center, banquet facilities, and conference/meeting rooms.

Wedding services and tour/ticket assistance are available. Guest parking is available for a surcharge. Additional property amenities include a terrace, multilingual staff, and currency exchange.

311 guestrooms at EPIC SANA Lisboa Hotel feature MP3 docking stations and minibars. Bathrooms feature separate bathtubs and showers, makeup/shaving mirrors, and hair dryers. Wireless Internet access is complimentary. Guestrooms offer desks and laptop-compatible safes.

LCD televisions are available in guestrooms. Rooms also include espresso makers.